Objective To explore the effects of parent-involved painting therapy on psychological state，quality of life and family function for children with leukemia. Methods Using a non-parallel controlled clinical trial design，a total of 40 children with leukemia and their parents who were admitted to a tertiary cancer hospital in Anhui Province from July 2021 to January 2022 were selected as the experimental group by convenience sampling，and the parent-involved painting therapy intervention program was implemented on the basis of routine care. 40 children with leukemia admitted from December 2020 to June 2021 and their parents were selected as the control group with routine care. The intervention time lasted 6 weeks for both groups. The anxiety level，depression level，quality of life and family function of the 2 groups were evaluated by the Screen for Child Anxiety Related Emotional Disorders（SCARED），the Depression Self-rating Scale for Children（DSRSC），the Family Adaptability and Cohesion Scale（PedsQL^TM 3.0） and the Pediatric Quality of Life Inventory 3.0 Cancer Module（FACES Ⅱ-CV） before intervention，after 3 weeks and 6 weeks of intervention. Results A total of 6 cases dropped out，and finally 36 cases were included in the experimental group and 38 cases in the control group. The comparison of anxiety level and family function at different time points between the 2 groups showed that the time effect, between-group effect and interaction effect were statistically significant（P<0.05）. There was no significant difference in depression level and quality of life among time effect, between-group effect and interaction effect（P>0.05）. The simple effect analysis showed that the anxiety level of the experimental group was lower than that of the control group after 3 weeks and 6 weeks, and the family function of the experimental group was better than that of the control group after 6 weeks, and the difference was statistically significant（P<0.05）. Conclusion Implementing parent-involved painting therapy can effectively reduce the anxiety of children with leukemia and improve their family function.

This article reported hospice care for a child with acute leukemia in the end-of-life stage,including the practical experience of using the concepts knowledge and skills of hospice care and nursing care for the child and his family members. The main points of nursing care include：conducting nursing care for symptoms of breathing difficulties and fever;carrying out family-participated painting therapy interventions,and children’s death education;holding a family meeting;using music,aromatherapy,and auricular acupoint therapy to relieve the insomnia symptoms of the children’s family members;using psychosocial therapy,family mourning,family dignity intervention,and writing letters that travel through time and space to relieve the complex grief of the children’s family members. The score of the Anticipatory Grief Scale dropped from 116 points to 76 points 6 months after the death,which achieved satisfactory results.